2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15726
    ICI 89406 53671-71-9 99.0%
    ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET.
    ICI 89406
  • HY-16912
    Petadeferitrin 911714-45-9 99.71%
    Petadeferitrin (SP-420) is a tridentate iron chelator belonging to the class of iron chelators, with orally activity. Petadeferitrin can be used in research related to β-thalassemia.
    Petadeferitrin
  • HY-17604
    Bexagliflozin 1118567-05-7 99.31%
    Bexagliflozin (EGT1442) is an orally active and selective SGLT2 inhibitor with IC50 values of 0.002 μM and 5.6 μM for SGLT2 and SGLT1, respectively. Bexagliflozin selectively inhibits SGLT2-mediated sodium-dependent glucose uptake. Bexagliflozin induces saturable urinary glucose excretion in normal rats and dogs. Bexagliflozin reduces blood glucose and HbA1c levels in db/db mice without affecting body mass or insulin level. Bexagliflozin can be used for the research of type 2 diabetes mellitus, hypertensive stroke.
    Bexagliflozin
  • HY-18013
    JNJ-40355003 1394894-41-7 99.81%
    JNJ-40355003 is a potent and selective atty acid amide hydrolase (FAAH) inhibitor.
    JNJ-40355003
  • HY-18080
    SA 47 792236-07-8 99.0%
    SA 47 is a selective and potent inhibitor of fatty acid amide hydrolase (FAAH) and carbamate.
    SA 47
  • HY-18734
    Carboxy-PTIO 145757-47-7 98%
    Carboxy-PTIO is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model.
    Carboxy-PTIO
  • HY-19616
    ML278 1604821-43-3
    ML278 is an efficient, low toxicity, and plasma stable SR-BI (IC50 = 6 nM) lipid uptake inhibitor. ML278 enhances HDL binding while inhibiting SR-BI mediated lipid uptake. ML278 can be used for research on metabolic conditions.
    ML278
  • HY-19627
    Naldemedine 916072-89-4 98%
    Naldemedine (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA). Naldemedine shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors. Naldemedine can be used in opioid-induced constipation (OIC) research. Naldemedine is predicted to bind to 3CLpro encoded by SARS-CoV2 genome.
    Naldemedine
  • HY-19650
    Pumosetrag Hydrochloride 194093-42-0 99.77%
    Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
    Pumosetrag Hydrochloride
  • HY-19727
    FOY 251 free base 71079-08-8 98%
    FOY 251 free base, an anti-proteolytic active metabolite of Camostate (HY-13512), acts as a proteinase inhibitor. FOY 25 free base inhibits SARS-CoV-2 infection in cells assay.
    FOY 251 free base
  • HY-23195
    Potassium 2-hydroxy-2-methylsuccinate 1030365-02-6 98.0%
    Potassium 2-hydroxy-2-methylsuccinate is an endogenous metabolite.
    Potassium 2-hydroxy-2-methylsuccinate
  • HY-44154
    PSB-CB5 1627710-30-8
    PSB-CB5 is a potent and selective antagonist of GRP18. PSB-CB5 has the potential for the research of metabolic disease and obesity.
    PSB-CB5
  • HY-50887
    L-873724 603139-12-4 98.93%
    L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption.
    L-873724
  • HY-59273
    5-Nitroindole 6146-52-7 99.30%
    5-Nitroindole is a mutagenic nitroarene and universal base analog. 5-Nitroindole significantly reduces the cellular adenylate energy charge by decreasing ATP levels and increasing AMP levels. 5-Nitroindole inhibits lipid peroxidation.
    5-Nitroindole
  • HY-75625
    2-Hydroxy-4-methoxybenzoic acid 2237-36-7 99.64%
    2-Hydroxy-4-methoxybenzoic acid is an orally active inhibitor of MCT-1 and MCT-4, as well as a plant biomarker. 2-Hydroxy-4-methoxybenzoic acid can be isolated from roots. 2-Hydroxy-4-methoxybenzoic acid induces Apoptosis and loss of mitochondrial membrane potential. 2-Hydroxy-4-methoxybenzoic acid exhibits anticancer activity against breast cancer. 2-Hydroxy-4-methoxybenzoic acid normalizes lactic acid levels. 2-Hydroxy-4-methoxybenzoic acid neutralizes viper venom and attenuates its lethal, hemorrhagic, coagulant and anticoagulant activities in male albino mice. 2-Hydroxy-4-methoxybenzoic acid possesses antihyperlipidemic, antidiabetic and hepatoprotective activities.
    2-Hydroxy-4-methoxybenzoic acid
  • HY-A0058
    Retinyl glucoside 136778-12-6 98%
    Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.
    Retinyl glucoside
  • HY-A0127
    Etofibrate 31637-97-5 99.80%
    Etofibrate is the ethandiol-1,2 diester of the nicotinic and clofibric acids. Etofibrate has been shown to be a potent hypolipidemic agent in animal and human.
    Etofibrate
  • HY-A0220
    Rescinnamine 24815-24-5
    Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research.
    Rescinnamine
  • HY-A0231
    Glymidine sodium 3459-20-9 98.48%
    Glymidine sodium is an oral active antidiabetic. Glymidine sodium is the inhibitor of hepatic lipolysis. Glymidine sodium inhibits the glucose formation and supresses the elevated pyruvate oxidation which results from the inhibition of endogenous lipid mobilization.
    Glymidine sodium
  • HY-B0544
    Sodium Picosulfate 10040-45-6 98.0%
    Sodium Picosulfate (Sodium Picosulphate) is a contact irritant laxative with oral activity. Sodium Picosulfate inhibits the absorption of water and electrolytes, increasing their production. Sodium Picosulfate can be used in colonoscopy applications.
    Sodium Picosulfate
Cat. No. Product Name / Synonyms Application Reactivity